The actress, who starred in Django Unchained and August: Osage Country, had been missing for ten days before her body was reportedly found by her friends and family.
Earlier tonight, a spokesperson confirmed the 32-year-old's body was found in a ravine while a police commander added there was currently no evidence “to believe there is foul play.”
Tributes have been paid to Misty by Juliette Lewis and Meryl Streep, who both worked with the star.
“So so sad to hear this news — all our thoughts are with her family and with her beautiful spirit,” wrote Meryl.
Juliette took to her Instagram to speak about Misty, writing: “Misty Upham survived many things that many don't early on in life. She fought for the voiceless fiercely. She understood suffering and the deepest pain. She had a presence everyone saw and felt.
“It is this presence that will continue. Out of the dark space in which her light got dimmed. I will remember her as tuff (tough). Wise. Funny. Spiritual.
And hopeful. This is another great reminder to call and check on someone when you think to. Not when its too late. RIPMistyUpham.”